p38 delta / MAPK13 Rabbit Polyclonal Antibody

Function

Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the MAPK13 gene. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.

Background References

1. Xing R et al. MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injury. Cell Discov. 2025 Feb

2. Kim J et al. MAPK13 stabilization via m(6)A mRNA modification limits anticancer efficacy of rapamycin. J Biol Chem. 2023 Sep

Subcellular Location

Cytoplasm, cytosol, nucleus.

UNIPROT

SwissProt: O15264 Human

Synonyms

Mitogen-activated protein kinase 13

EC:2.7.11.24

MAP kinase 13

MAPK 13

Mitogen-activated protein kinase p38 delta

MAP kinase p38 delta

Stress-activated protein kinase 4

MAPK13

PRKM13

SAPK4