CD105 Mouse Monoclonal Antibody [A5E8]
Catalog# HA600077
CD105 Mouse Monoclonal Antibody [A5E8]
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WB
-
Human
-
unconjugated
Overview
Product Name
CD105 Mouse Monoclonal Antibody [A5E8]
Antibody Type
Mouse Monoclonal Antibody
Immunogen
Recombinant protein within human CD105 aa 101-300.
Species Reactivity
Human
Validated Applications
WB
Molecular Weight
Predicted band size: 71 kDa
Positive Control
Hela cell lysate, HepG2 cell lysate.
Conjugation
unconjugated
Clone Number
A5E8
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG2b
Purification Method
Protein G affinity purified.
Application Dilution
-
WB
-
1:500
Target
Function
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Background References
1. Wang X. et. al. CD105 overexpression mediates drug-resistance in choriocarcinoma cells through BMP9/Smad pathway. J Cancer. 2020 Jan
2. Kauer J. et. al. CD105 (Endoglin) as negative prognostic factor in AML. Sci Rep. 2019 Dec
Subcellular Location
Cell membrane.
UNIPROT
Synonyms
AI528660 antibody
AI662476 antibody
CD 105 antibody
CD105 antibody
CD105 antigen antibody
EGLN_HUMAN antibody
END antibody
Endoglin antibody
Eng antibody
FLJ41744 antibody
ExpandImages
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Western blot analysis of CD105 on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (HA600077, 1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Mouse IgG - HRP Secondary Antibody (HA1006) at 1:20,000 dilution was used for 1 hour at room temperature.
Positive control:
Lane 1: Hela cell lysate
Lane 2: HepG2 cell lysate
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Products with the same target and pathway
CD105 Recombinant Rabbit Monoclonal Antibody [JE60-59]
Application: WB,IHC-P,IF-Tissue
Reactivity: Human
Conjugate: unconjugated
CD105 Rabbit Polyclonal Antibody
Application: WB,IHC-P
Reactivity: Human
Conjugate: unconjugated
