FITC Conjugated Human CD11b Recombinant Mouse Monoclonal Antibody [A2-9-R]
Catalog# HA600130F
FITC Conjugated Human CD11b Recombinant Mouse Monoclonal Antibody [A2-9-R]
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FC
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Human
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FITC
Overview
Product Name
FITC Conjugated Human CD11b Recombinant Mouse Monoclonal Antibody [A2-9-R]
Antibody Type
Recombinant Mouse Monoclonal Antibody
Immunogen
Recombinant protein within Human CD11b aa 544-743 / 1,152.
Species Reactivity
Human
Validated Applications
FC
Molecular Weight
Predicted band size: 127 kDa
Positive Control
Human peripheral blood.
Conjugation
FITC
Clone Number
A2-9-R
Product Features
Form
Liquid
Concentration
Storage Instructions
Store at 2℃ to 8℃. Avoid repeated freeze / thaw cycles.
Storage Buffer
Supplied in phosphate-buffered solution, pH 7.2, containing 0.2% ProClean 950 and BSA.
Isotype
IgG1
Purification Method
Protein G affinity purified.
Application Dilution
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FC
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5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Target
Function
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development.
Background References
1. Jerke U et al.Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation. J. Biol. Chem. 286:7070-7081 (2011).
2. Bai M. et al. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood 0:0-0 (2017).
Subcellular Location
Cell membrane.
UNIPROT
Synonyms
antigen CD11b (p170) antibody
Antigen CD11b p170 antibody
CD11 antigen like family member B antibody
CD11 antigen-like family member B antibody
CD11b antibody
CD11b/CD18 antibody
CD49d antibody
Cell surface glycoprotein MAC-1 subunit alpha antibody
Complement component 3 receptor 3 subunit antibody
Complement Component Receptor 3 Alpha antibody
ExpandImages
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Flow cytometric analysis of human peripheral blood labelling Human CD11b (HA600130F, FITC).
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"