IL-28A Mouse Monoclonal Antibody [A5D7] (HA601026)

UNIPROT #

Q8IZJ0

PROTEIN NAME

IL-28A

SYNONYMS

Cytokine ZCYTO20 antibody;IFN-lambda-2 antibody;IFNL2 antibody;IL-28A antibody;IL28A antibody;IL28A_HUMAN antibody;Interferon lambda 2 antibody;Interferon lambda-2 antibody;interleukin 28A (interferon, lambda 2) antibody;Interleukin 28A antibody;Interleukin-28A antibody;ZCYTO20 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.