xCT/SLC7A11 Recombinant Mouse Monoclonal Antibody [A7C6-R] (HA601071)
Catalog# HA601071
Mouse Monoclonal to xCT/SLC7A11
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WB
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IHC-P
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IF-Cell
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FC
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Human
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Mouse
Lane 1: HT-29 cell lysate
Lane 2: A549 cell lysate
Lysates/proteins at 10 µg/Lane.
Predicted band size: 55 kDa
Observed band size: 55 kDa
Exposure time: 30 seconds;
10% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA601071) at 1/500 dilution was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Mouse IgG - HRP Secondary Antibody (HA1006) at 1:100,000 dilution was used for 1 hour at room temperature.
Specifications
Product Type
Recombinant Mouse monoclonal primary
Product Name
xCT/SLC7A11 Recombinant Mouse Monoclonal Antibody [A7C6-R] (HA601071)
Immunogen
293 cell line overexpressing slc7a11.
Host
Mouse
Positive Control
HT-29 cell lysate, A549 cell lysate, HCT116 cell lysates, human pancreas tissue, HT-29, NIH/3T3 cell lysates.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
A7C6-R
RRID
APPLICATION DILUTION
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WB
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1:500-1:5,000
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IHC-P
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1:200
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IF-Cell
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1:100-1:200
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FC
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1:1,000
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
Predicted band size: 55 kDa
Isotype
IgG1
TARGET
UNIPROT #
PROTEIN NAME
xCT/SLC7A11
SYNONYMS
Amino acid transport system xc xCT antibody antibody;Amino acid transport system xc- antibody;Calcium channel blocker resistance protein CCBR1 antibody;Calcium channel blocker resistance protein CCBR1 antibody antibody;CCBR1 antibody;Cysteine/glutamate transporter antibody antibody;Cystine/glutamate transporter antibody;OTTHUMP00000164578 antibody;SLC7A11 antibody;Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 antibody;solute carrier family 7 antibody;Solute carrier family 7 member 11 antibody;Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 antibody;SYSTEM Xc(-) TRANSPORTER-RELATED PROTEIN antibody;xCT antibody;XCT_HUMAN antibody
SUBCELLULAR LOCATION
Cell membrane, Cell projection, microvillus membrane.
FUNCTION
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.
CITATIONS
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Xiao Juan,et al
Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling
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WB
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IF
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Rat
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Human
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Citation
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Shu Guangjie,et al
Galangin alleviated Doxorubicin-induced cardiotoxicity by inhibiting ferroptosis through GSTP1/JNK pathway
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WB
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Rat
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Citation
-
-
Zhang Shenshen,et al
Ferroptosis Exists in Ischemia Reperfusion Injury after Cardiac Surgery with Cardiopulmonary Bypass
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WB
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Human
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Citation
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-
Dihydroartemisinin inhibits the growth of pancreatic cells by inducing ferroptosis and activating antitumor immunity
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WB
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Mouse
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Citation
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Liang Xiaoliu,et al
Rhein‐based Pickering emulsion for hepatocellular carcinoma: Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization
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WB
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Human
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Citation
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