EGFR Mouse Monoclonal Antibody [A8E12] (HA601073)

UNIPROT #

P00533

PROTEIN NAME

EGFR

SYNONYMS

Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody;Cell growth inhibiting protein 40 antibody;Cell proliferation inducing protein 61 antibody;EGF R antibody;EGFR antibody;EGFR_HUMAN antibody;Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) antibody;Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian) antibody;Epidermal growth factor receptor antibody;erb-b2 receptor tyrosine kinase 1 antibody;ERBB antibody;ERBB1 antibody;Errp antibody;HER1 antibody;mENA antibody;NISBD2 antibody;Oncogen ERBB antibody;PIG61 antibody;Proto-oncogene c-ErbB-1 antibody;Receptor tyrosine protein kinase ErbB 1 antibody;Receptor tyrosine-protein kinase ErbB-1 antibody;SA7 antibody;Species antigen 7 antibody;Urogastrone antibody;v-erb-b Avian erythroblastic leukemia viral oncogen homolog antibody;wa2 antibody;Wa5 antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum, Cell membrane, Endosome, Nucleus, Golgi apparatus.

FUNCTION

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration. Plays a role in enhancing learning and memory performance. Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.