ACVR2A Mouse Monoclonal Antibody [A7C8]
Catalog# HA601091
ACVR2A Mouse Monoclonal Antibody [A7C8]
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WB
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Human
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unconjugated
Overview
Product Name
ACVR2A Mouse Monoclonal Antibody [A7C8]
Antibody Type
Mouse Monoclonal Antibody
Immunogen
Synthetic peptide within Human ACVR2A aa 464-513 / 513.
Species Reactivity
Human
Validated Applications
WB
Molecular Weight
Predicted band size: 58 kDa
Positive Control
K562 cell lysate, HepG2 cell lysate.
Conjugation
unconjugated
Clone Number
A7C8
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG1
Purification Method
Protein A affinity purified.
Application Dilution
-
WB
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1:1,000
Target
Function
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.
Background References
1. Zhao L. et. al. Microsatellite Instability-Related ACVR2A Mutations Partially Account for Decreased Lymph Node Metastasis in MSI-H Gastric Cancers. Onco Targets Ther. 2020 May
2. Schang G. et. al. Murine FSH Production Depends on the Activin Type II Receptors ACVR2A and ACVR2B. Endocrinology. 2020 Jul
Subcellular Location
Membrane.
UNIPROT
Synonyms
Activin A receptor type IIA antibody
Activin receptor type 2A antibody
Activin receptor type IIA antibody
Activin receptor type-2A antibody
ACTR 2 antibody
ACTR IIA antibody
ACTR-IIA antibody
ACTR2 antibody
ACTRII antibody
ACTRIIA antibody
ExpandImages
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Western blot analysis of ACVR2A on different lysates with Mouae anti-ACVR2A antibody (HA601091) at 1/1,000 dilution.
Lane 1: K562 cell lysate
Lane 2: HepG2 cell lysate
Lysates/proteins at 10 µg/Lane.
Predicted band size: 58 kDa
Observed band size: 50 kDa
Exposure time: 1 minute;
10% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA601091) at 1/1,000 dilution was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Mouse IgG - HRP Secondary Antibody (HA1006) at 1:300,000 dilution was used for 1 hour at room temperature.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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