PSMA Mouse Monoclonal Antibody [A9H9] (HA601164)

UNIPROT #

Q04609

PROTEIN NAME

PSMA

SYNONYMS

Cell growth inhibiting protein 27 antibody;Cell growth-inhibiting gene 27 protein antibody;FGCP antibody;Folate hydrolase (prostate-specific membrane antigen) 1 antibody;Folate hydrolase 1 antibody;Folate hydrolase antibody;Folate hydrolase prostate specific membrane antigen 1 antibody;FOLH 1 antibody;FOLH antibody;Folh1 antibody;FOLH1_HUMAN antibody;Folylpoly gamma glutamate carboxypeptidase antibody;Folylpoly-gamma-glutamate carboxypeptidase antibody;GCP 2 antibody;GCP II antibody;GCP2 antibody;GCPII antibody;GIG27 antibody;Glutamate carboxylase II antibody;Glutamate carboxypeptidase 2 antibody;Glutamate carboxypeptidase II antibody;Membrane glutamate carboxypeptidase antibody;mGCP antibody;N acetylated alpha linked acidic dipeptidase 1 antibody;N-acetylated-alpha-linked acidic dipeptidase I antibody;NAALAD 1 antibody;NAALAD1 antibody;NAALAdase antibody;NAALADase I antibody;Prostate specific membrane antigen antibody;Prostate specific membrane antigen variant F antibody;Prostate-specific membrane antigen antibody;PSM antibody;PSMA antibody;Pteroylpoly gamma glutamate carboxypeptidase antibody;Pteroylpoly-gamma-glutamate carboxypeptidase antibody

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm.

FUNCTION

Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase, or prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene. Human GCPII contains 750 amino acids and weighs approximately 84 kDa. GCPII is a zinc metalloenzyme that resides in membranes. Most of the enzyme resides in the extracellular space. GCPII is a class II membrane glycoprotein. It catalyzes the hydrolysis of N-acetylaspartylglutamate (NAAG) to glutamate and N-acetylaspartate (NAA) according to the reaction scheme to the right. Neuroscientists primarily use the term NAALADase in their studies, while those studying folate metabolism use folate hydrolase, and those studying prostate cancer or oncology, PSMA. All refer to the same protein glutamate carboxypeptidase II.