SLC40A1 Mouse Monoclonal Antibody [A10A1] (HA601178)

UNIPROT #

Q9NP59

PROTEIN NAME

SLC40A1

SYNONYMS

Ferroportin 1 antibody;Ferroportin antibody;Ferroportin-1 antibody;FPN1 antibody;HFE4 antibody;IREG1 antibody;iron regulated gene 1 antibody;Iron regulated transporter 1 antibody;Iron-regulated transporter 1 antibody;MST079 antibody;MSTP079 antibody;MTP1 antibody;putative ferroportin 1 variant IIIA antibody;putative ferroportin 1 variant IIIB antibody;S40A1_HUMAN antibody;SLC11A3 antibody;SLC11A3, formerly antibody;SLC40A1 antibody;solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3 antibody;solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3, formerly antibody;solute carrier family 40 (iron-regulated transporter), member 1 antibody;Solute carrier family 40 member 1 antibody

SUBCELLULAR LOCATION

Cell membrane, Basolateral cell membrane.

FUNCTION

Ferroportin-1, also known as solute carrier family 40 member 1 (SLC40A1) or iron-regulated transporter 1 (IREG1), is a protein that in humans is encoded by the SLC40A1 gene, and is part of the Ferroportin (Fpn) Family. Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of the cell. Ferroportin is the only known iron exporter. After dietary iron is absorbed into the cells of the small intestine, ferroportin allows that iron to be transported out of those cells and into the bloodstream. Fpn also mediates the efflux of iron recycled from macrophages resident in the spleen and liver. Ferroportin is regulated by hepcidin, a hormone produced by the liver; hepcidin binds to Fpn and limits its iron-efflux activity, thereby reducing iron delivery to the blood plasma. Therefore, the interaction between Fpn and hepcidin controls systemic iron homeostasis.