UBA3 Recombinant Mouse Monoclonal Antibody [1C10-5-5-R] (HA601234)

UNIPROT #

Q8TBC4

PROTEIN NAME

UBA3

SYNONYMS

DKFZp566J164 antibody;EC 6.3.2. antibody;hUba3 antibody;MGC22384 antibody;NEDD8 activating enzyme E1 catalytic subunit antibody;NEDD8 activating enzyme E1C antibody;Nedd8 activating enzyme hUba3 antibody;NEDD8-activating enzyme E1 catalytic subunit antibody;NEDD8-activating enzyme E1C antibody;uba3 antibody;UBA3 ubiquitin activating enzyme E1 homolog antibody;UBA3_HUMAN antibody;UBE1C antibody;Ubiquitin activating enzyme 3 antibody;Ubiquitin activating enzyme E1C antibody;Ubiquitin-activating enzyme 3 antibody;Ubiquitin-activating enzyme E1C antibody;Ubiquitin-like modifier-activating enzyme 3 antibody

SUBCELLULAR LOCATION

Cytosol, nucleus, cytoplasm.

FUNCTION

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.