MCM7 Recombinant Mouse Monoclonal Antibody [15E1-R]

Function

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.

Background References

1. Hallén T et al. MCM7 as a marker of postsurgical progression in non-functioning pituitary adenomas. Eur J Endocrinol. 2021 Apr

2. Ravindran E et al. Homozygous mutation in MCM7 causes autosomal recessive primary microcephaly and intellectual disability. J Med Genet. 2022 May

Subcellular Location

Nucleus.

UNIPROT

SwissProt: P33993 Human

SwissProt: Q61881 Mouse

Entrez Gene: 288532 Rat

Synonyms