Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (By similarity). Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.
Background References
1. Hong L., Tang Y., Pan S., Xu M., Shi Y., Gao S., Sui C., He C., Zheng K., Tang R., Shi Z., Wang Q., Wang H. Interleukin 3-induced GITR promotes the activation of human basophils. Cytokine 136:155268-155268 (2020).
2. Lopez C., Zamorano P., Teuber S., Salas M., Otth C., Hidalgo M.A., Concha I., Zambrano A. Interleukin-3 Prevents Cellular Death Induced by Oxidative Stress in HEK293 Cells. J. Cell. Biochem. 118:1330-1340 (2017).
