LRP4 Recombinant Mouse Monoclonal Antibody [PSH10-25]
Catalog# HA601381
LRP4 Recombinant Mouse Monoclonal Antibody [PSH10-25]
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WB
-
Mouse
-
Rat
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HA610226
不含抗保成分
-
unconjugated
Overview
Product Name
LRP4 Recombinant Mouse Monoclonal Antibody [PSH10-25]
Antibody Type
Recombinant Mouse Monoclonal Antibody
Immunogen
Recombinant protein within mouse LRP4 aa 1747-1905.
Species Reactivity
Mouse, Rat
Validated Applications
WB
Molecular Weight
Predicted band size: 212 kDa
Positive Control
Rat kidney tissue lysates.
Conjugation
unconjugated
Clone Number
PSH10-25
Reactivity Data
| WB | |
|---|---|
| Mouse |
|
| Rat |
|
| Human |
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG1
Purification Method
Protein A affinity purified.
Application Dilution
-
WB
-
1:2,000
Target
Function
Low-density lipoprotein receptor-related protein 4 (LRP-4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a protein that in humans is encoded by the LRP4 gene. LRP-4 is a member of the Lipoprotein receptor-related protein family and may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani Lenz syndactylism. Autoantibodies against LRP4 have been connected to a small fraction of myasthenia gravis cases.
Background References
1. Chen BH et al. LRP4-related signalling pathways and their regulatory role in neurological diseases. Brain Res. 2024 Feb
2. Chuquisana O et al. Functional Signature of LRP4 Antibodies in Myasthenia Gravis. Neurol Neuroimmunol Neuroinflamm. 2024 May
Subcellular Location
Cell membrane.
Synonyms
KIAA0816 antibody
LDLR dan antibody
Low density lipoprotein receptor related protein 4 antibody
Low-density lipoprotein receptor-related protein 4 antibody
LRP-4 antibody
LRP10 antibody
Lrp4 antibody
LRP4_HUMAN antibody
MEGF7 antibody
Multiple epidermal growth factor like domains 7 antibody
ExpandImages
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Western blot analysis of LRP4 on rat kidney tissue lysates with Mouse anti-LRP4 antibody (HA601381) at 1/2,000 dilution.
Lysates/proteins at 30 µg/Lane.
Predicted band size: 212 kDa
Observed band size: 250 kDa
Exposure time: 1 minute 18 seconds; ECL: K1801;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA601381) at 1/2,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Mouse IgG - HRP Secondary Antibody (HA1006) at 1/50,000 dilution was used for 1 hour at room temperature.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"