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LRP4 Recombinant Mouse Monoclonal Antibody [PSH10-25]

Usd: 350

Specification

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Catalog# HA601381

LRP4 Recombinant Mouse Monoclonal Antibody [PSH10-25]

Application

  • WB

Reactivity

  • Mouse

  • Rat

BSA and Azide free
Conjugation

  • unconjugated

Overview

Product Name

LRP4 Recombinant Mouse Monoclonal Antibody [PSH10-25]

Antibody Type

Recombinant Mouse Monoclonal Antibody

Immunogen

Recombinant protein within mouse LRP4 aa 1747-1905.

Species Reactivity

Mouse, Rat

Validated Applications

WB

Target Molecular Weight

Predicted band size: 212 kDa

Positive Control

Rat kidney tissue lysates.

Conjugation

unconjugated

Clone Number

PSH10-25

Reactivity Data

WB
Mouse
Tested Tested
Rat
Tested Tested
Human

Product Features

Form

Liquid

Concentration

1 mg/mL.(The concentration of this product may be batch-dependent)

Storage Instructions

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.

Storage Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Isotype

IgG1

Purification Method

Protein A affinity purified.

Application Dilution

  • WB

  • 1:2,000

Target

Function

Low-density lipoprotein receptor-related protein 4 (LRP-4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a protein that in humans is encoded by the LRP4 gene. LRP-4 is a member of the Lipoprotein receptor-related protein family and may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani Lenz syndactylism. Autoantibodies against LRP4 have been connected to a small fraction of myasthenia gravis cases.

Background References

1. Chen BH et al. LRP4-related signalling pathways and their regulatory role in neurological diseases. Brain Res. 2024 Feb

2. Chuquisana O et al. Functional Signature of LRP4 Antibodies in Myasthenia Gravis. Neurol Neuroimmunol Neuroinflamm. 2024 May

Subcellular Location

Cell membrane.

UNIPROT

SwissProt: Q8VI56 Mouse

SwissProt: Q9QYP1 Rat

Synonyms

KIAA0816 antibody

LDLR dan antibody

Low density lipoprotein receptor related protein 4 antibody

Low-density lipoprotein receptor-related protein 4 antibody

LRP-4 antibody

LRP10 antibody

Lrp4 antibody

LRP4_HUMAN antibody

MEGF7 antibody

Multiple epidermal growth factor like domains 7 antibody

Expand

Images

  • Western blot analysis of LRP4 on rat kidney tissue lysates with Mouse anti-LRP4 antibody (<a href="/products/HA601381" style="font-weight: bold;text-decoration: underline;">HA601381</a>) at 1/2,000 dilution.<br /><br />Lysates/proteins at 30 µg/Lane.<br /><br />Predicted band size: 212 kDa<br />Observed band size: 250 kDa<br /><br />Exposure time: 1 minute 18 seconds; ECL: K1801;<br /><br />4-20% SDS-PAGE gel.<br /><br />Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (<a href="/products/HA601381" style="font-weight: bold;text-decoration: underline;">HA601381</a>) at 1/2,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Mouse IgG - HRP Secondary Antibody (<a href="/products/HA1006" style="font-weight: bold;text-decoration: underline;">HA1006</a>) at 1/50,000 dilution was used for 1 hour at room temperature.

    Western blot analysis of LRP4 on rat kidney tissue lysates with Mouse anti-LRP4 antibody (HA601381) at 1/2,000 dilution.

    Lysates/proteins at 30 µg/Lane.

    Predicted band size: 212 kDa
    Observed band size: 250 kDa

    Exposure time: 1 minute 18 seconds; ECL: K1801;

    4-20% SDS-PAGE gel.

    Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA601381) at 1/2,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Mouse IgG - HRP Secondary Antibody (HA1006) at 1/50,000 dilution was used for 1 hour at room temperature.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"