CD127 Recombinant Mouse Monoclonal Antibody [PSH12-76]
Catalog# HA601429
CD127 Recombinant Mouse Monoclonal Antibody [PSH12-76]
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FC
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Human
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unconjugated
Overview
Product Name
CD127 Recombinant Mouse Monoclonal Antibody [PSH12-76]
Antibody Type
Recombinant Mouse Monoclonal Antibody
Immunogen
Recombinant protein within Human CD127 aa 21-239 (Extracellular).
Species Reactivity
Human
Validated Applications
FC
Molecular Weight
Predicted band size: 52 kDa
Positive Control
Human peripheral blood lymphocytes.
Conjugation
unconjugated
Clone Number
PSH12-76
Reactivity Data
| FC | |
|---|---|
| Human |
|
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 1% BSA, 0.2% Proclean 950.
Isotype
IgG1
Purification Method
Protein A affinity purified.
Application Dilution
-
FC
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1:1,000
Target
Function
Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R gene. IL7R-α is a type I cytokine receptor and is a subunit of the functional interleukin-7 receptor and thymic stromal lymphopoietin (TSLP) receptors.
Background References
1. Zhang B et al. CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases. J Exp Med. 2022 Feb
2. Liang KL et al. Circulating IRF8-expressing CD123(+)CD127(+) lymphoid progenitors: key players in human hematopoiesis. Trends Immunol. 2023 Sep
Subcellular Location
Cell membrane; Secreted.
UNIPROT
Synonyms
CD 127 antibody
CD127 antibody
CD127 antigen antibody
CDw127 antibody
IL 7R alpha antibody
IL 7R antibody
IL-7 receptor subunit alpha antibody
IL-7R subunit alpha antibody
IL-7R-alpha antibody
IL-7RA antibody
ExpandImages
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Flow cytometric analysis of human peripheral blood lymphocytes labeling CD127.
Cells were washed twice with cold PBS and resuspend. Then stained with the primary antibody (HA601429, 1/1,000) (red). After incubation of the primary antibody at +4℃ for an hour, the cells were stained with a iFluor™ 488 conjugate-Goat anti-Mouse IgG Secondary antibody (HA1125) at 1/1,000 dilution for 30 minutes at +4℃. Unlabelled sample was used as a control (cells without incubation with primary antibody; black).
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"