FITC Conjugated Human IgD Recombinant Mouse Monoclonal Antibody [PSH14-48]
Catalog# HA601526F
FITC Conjugated Human IgD Recombinant Mouse Monoclonal Antibody [PSH14-48]
-
FC
-
Human
-
FITC
Overview
Product Name
FITC Conjugated Human IgD Recombinant Mouse Monoclonal Antibody [PSH14-48]
Antibody Type
Recombinant Mouse Monoclonal Antibody
Species Reactivity
Human
Validated Applications
FC
Target Molecular Weight
Predicted band size: 56 kDa
Positive Control
Human peripheral blood cells.
Conjugation
FITC
Clone Number
PSH14-48
Reactivity Data
| FC | |
|---|---|
| Human |
|
Product Features
Form
Liquid
Concentration
/(The concentration of this product may be batch-dependent)
Storage Instructions
Store at 2-8℃. Avoid freeze.
Storage Buffer
1*PBS (pH7.4), 1% BSA, 0.2% Proclean 950.
Isotype
IgG1
Purification Method
Protein A affinity purified.
Application Dilution
-
FC
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5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Target
Function
IgD is the major antigen receptor isotype on the surface of most peripheral B cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum is below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.
Background References
暂无
Subcellular Location
Secreted, Cell membrane.
UNIPROT
Images
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"