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TCR beta chain Recombinant Mouse Monoclonal Antibody [PSH16-30]

Usd: 35

Specification

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Catalog# HA601535

TCR beta chain Recombinant Mouse Monoclonal Antibody [PSH16-30]

Application

  • FC

Reactivity

  • Mouse

BSA and Azide free
Conjugation

  • unconjugated

Overview

Product Name

TCR beta chain Recombinant Mouse Monoclonal Antibody [PSH16-30]

Antibody Type

Recombinant Mouse Monoclonal Antibody

Species Reactivity

Mouse

Validated Applications

FC

Positive Control

Mouse splenocytes.

Conjugation

unconjugated

Clone Number

PSH16-30

Product Features

Form

Liquid

Concentration

Storage Instructions

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

1*PBS (pH7.4), 1% BSA, 0.2% Proclean 950.

Isotype

IgG1

Purification Method

Protein A affinity purified.

Application Dilution

  • FC

  • 1:1,000

Target

Function

T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR-β is a member of the immunoglobulin superfamily and a component of the CD3/TCR complex (along with TCR-α). It is expressed on α/β TCR-bearing T cells and thymocytes. The CD3/TCR complex plays a key role in antigen recognition, signal transduction, and T cell activation.

Background References

1. Dutta A et al. New insights into TCR beta-selection. Trends Immunol. 2021 Aug

2. Li G et al. TCR beta chain repertoire characteristic between healthy human CD4+ and CD8+ T cells. Biosci Rep. 2024 Mar

Subcellular Location

Cell membrane.

UNIPROT

Entrez Gene: 21577 Mouse

Synonyms

MGC108929 antibody

MGC109620 antibody

MGC116333 antibody

MGC152215 antibody

MGC157076 antibody

MGC159579 antibody

MGC159580 antibody

RATTCB antibody

RATTCBC1 antibody

T cell antigen receptor, beta polypeptide, T cell receptor, beta cluster antibody

Expand

Images

  • Flow cytometric analysis of mouse splenocytes labeling TCR beta chain.<br /><br />Cells were washed twice with cold PBS and resuspend. Then stained with the primary antibody (<a href="/products/HA601535" style="font-weight: bold;text-decoration: underline;">HA601535</a>, 1/1,000) (red) compared with Mouse IgG Isotype Control (green). After incubation of the primary antibody at +4℃ for an hour, the cells were stained with a iFluor&trade; 488 conjugate-Goat anti-Mouse IgG Secondary antibody (<a href="/products/HA1125" style="font-weight: bold;text-decoration: underline;">HA1125</a>) at 1/1,000 dilution for 30 minutes at +4℃. Unlabelled sample was used as a control (cells without incubation with primary antibody; black).

    Flow cytometric analysis of mouse splenocytes labeling TCR beta chain.

    Cells were washed twice with cold PBS and resuspend. Then stained with the primary antibody (HA601535, 1/1,000) (red) compared with Mouse IgG Isotype Control (green). After incubation of the primary antibody at +4℃ for an hour, the cells were stained with a iFluor™ 488 conjugate-Goat anti-Mouse IgG Secondary antibody (HA1125) at 1/1,000 dilution for 30 minutes at +4℃. Unlabelled sample was used as a control (cells without incubation with primary antibody; black).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"