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VAChT / SLC18A3 Recombinant Antibody [PSH10-50] - Mouse IgG1 (Chimeric) - BSA and Azide free (HA610311)

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Catalog# HA610311

to VAChT / SLC18A3

Tested for

  • IHC-Fr

  • IHC-P

Reacts with

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Chimeric Antibody primary

Product Name

VAChT / SLC18A3 Recombinant Antibody [PSH10-50] - Mouse IgG1 (Chimeric) - BSA and Azide free (HA610311)

Immunogen

Recombinant protein within n terminal mouse vacht.

Positive Control

Mouse brain (striatum) tissue, rat brain (striatum) tissue.

Conjugation

Unconjugated

Clone Number

PSH10-50

APPLICATION DILUTION

  • IHC-Fr

  • 1:200

  • IHC-P

  • 1:500

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4).

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 57 kDa

TARGET

UNIPROT #

O35304

PROTEIN NAME

VAChT / SLC18A3

SYNONYMS

AChR antibody;MGC12716 antibody;rVAT antibody;Slc18a3 antibody;Solute carrier family 18 (vesicular acetylcholine) member 3 antibody;Solute carrier family 18 (vesicular monoamine) member 3 antibody;Solute carrier family 18 member 3 antibody;VAChT antibody;VACHT_HUMAN antibody;Vesicular acetylcholine transporter antibody

SUBCELLULAR LOCATION

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane.

FUNCTION

The Vesicular acetylcholine transporter (VAChT) is a neurotransmitter transporter which is responsible for loading acetylcholine (ACh) into secretory organelles in neurons making acetylcholine available for secretion. It is encoded by Solute carrier family 18, member 3 (SLC18A3) gene, located within the first intron of the choline acetyltransferase gene. VAChT is able to transport ACh into vesicles by relying on an exchange between protons (H+) that were previously pumped into the vesicle diffusing out, thus acting as an antiporter. ACh molecules are then carried into the vesicle by the action of exiting protons. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase.

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