Collagen III Recombinant Rabbit Monoclonal Antibody [JE60-79] (HA720050)

UNIPROT #

P02461

PROTEIN NAME

Collagen III

SYNONYMS

Alpha 1 type III collagen antibody;Alpha1 (III) collagen antibody;CO3A1_HUMAN antibody;COL 3A1 antibody;COL3A1 antibody;Collagen alpha 1(III) chain antibody;Collagen alpha-1(III) chain antibody;Collagen III alpha 1 chain precursor antibody;Collagen III alpha 1 polypeptide antibody;Collagen type III alpha 1 (Ehlers Danlos syndrome type IV autosomal dominant) antibody;Collagen type III alpha 1 antibody;Collagen type III alpha 1 chain antibody;Collagen type III alpha antibody;Collagen, fetal antibody;EDS4A antibody;Ehlers Danlos syndrome type IV, autosomal dominant antibody;Fetal collagen antibody;Type III collagen antibody

SUBCELLULAR LOCATION

Extracellular matrix.

FUNCTION

Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.