iFluor™ 488 Conjugated Cytokeratin 6 Recombinant Rabbit Monoclonal Antibody [SN71-07] (HA720130F)

UNIPROT #

P02538

PROTEIN NAME

Cytokeratin 6

SYNONYMS

CK6 antibody;CK 6A antibody;CK 6B antibody;CK 6C antibody;CK 6D antibody;CK 6E antibody;CK-6B antibody;CK-6C antibody;CK-6E antibody;Cytokeratin 6a antibody;Cytokeratin 6B antibody;Cytokeratin 6C antibody;Cytokeratin 6D antibody;Cytokeratin 6E antibody;Cytokeratin-6B antibody;Cytokeratin-6C antibody;Cytokeratin-6E antibody;K2C6C_HUMAN antibody;K6a keratin antibody;K6b keratin antibody;K6C antibody;K6c keratin antibody;K6d keratin antibody;K6e keratin antibody;Keratin antibody;Keratin K6h antibody;Keratin type II cytoskeletal 6A antibody;Keratin type II cytoskeletal 6B antibody;Keratin type II cytoskeletal 6C antibody;Keratin type II cytoskeletal 6D antibody;Keratin type II cytoskeletal 6E antibody;Keratin-6C antibody;KRT6A antibody;KRT6B antibody;KRT6C antibody;KRT6D antibody;KRT6E antibody;type II cytoskeletal 6C antibody;Type-II keratin Kb12 antibody

SUBCELLULAR LOCATION

Keratin filament, cytosol, extracellular exosome, nucleus, membrane.

FUNCTION

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins, which are useful markers of tissue differentiation, also aid in the characterization of malignant tumors. IL-1 and TNFα induce transcription of cytokeratin 6 in epidermal keratinocytes via the C/EBP β transcription factor. In humans, multiple isoforms of cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies.