iFluor™ 647 Conjugated SATB2 Recombinant Rabbit Monoclonal Antibody [JM52-44] (HA720173F)

UNIPROT #

Q9UPW6

PROTEIN NAME

SATB2

SYNONYMS

DNA binding protein SATB2 antibody;DNA-binding protein SATB2 antibody;FLJ21474 antibody;FLJ32076 antibody;GLSS antibody;KIAA1034 antibody;MGC119474 antibody;MGC119477 antibody;SATB family member 2 antibody;SATB homeobox 2 antibody;SATB2 antibody;SATB2_HUMAN antibody;Special AT rich sequence binding protein 2 antibody;Special AT-rich sequence-binding protein 2 antibody

SEQUENCE SIMILARITIES

Belongs to the CUT homeobox family.

TISSUE SPECIFICITY

High expression in adult brain, moderate expression in fetal brain, and weak expression in adult liver, kidney, and spinal cord and in select brain regions, including amygdala, corpus callosum, caudate nucleus, and hippocampus.

POST-TRANSLATIONAL MODIFICATION

Sumoylated by PIAS1. Sumoylation promotes nuclear localization, but represses transcription factor activity.

SUBCELLULAR LOCATION

Nucleus matrix.

FUNCTION

SATB2 (Special AT-rich sequence-binding protein 2) is a nuclear matrix protein that influences craniofacial formation mechanisms, such as jaw and palate development, and is part of a transcriptional network regulating skeletal development and osteoblast differentiation. Highly expressed in adult and fetal brain, SATB2 contains two CUT DNA-binding domains and one homeobox domain and is closely related to SATB1, a transcriptional repressor. SATB2 is thought to bind to matrix-attachment regions (MARs) and regulate MAR-dependent transcription of various genes, including HoxA2 and ATF4 (CREB-2), involved in skeletal development. Functioning as both a transcriptional activator and repressor, SATB2 can also act as a protein scaffold that can enhance the activity of other DNA-binding proteins. Defects in the gene encoding SATB2 are the cause of cleft palate manifested in conjunction with severe mental retardation.