iFluor™ 488 Conjugated NSE Recombinant Rabbit Monoclonal Antibody [SC06-28] (HA720178F)

UNIPROT #

P09104

PROTEIN NAME

NSE

SYNONYMS

2 phospho D glycerate hydrolyase antibody;2-phospho-D-glycerate hydro-lyase antibody;Eno 2 antibody;ENO2 antibody;ENOG antibody;ENOG_HUMAN antibody;Enolase 2 (gamma, neuronal) antibody;Enolase 2 antibody;Enolase 2 gamma neuronal antibody;Enolase2 antibody;Epididymis secretory protein Li 279 antibody;Gamma enolase antibody;Gamma-enolase antibody;HEL S 279 antibody;Neural enolase antibody;Neuron specific enolase antibody;Neuron specific gamma enolase antibody;Neuron-specific enolase antibody;Neurone specific enolase antibody;NSE antibody

SEQUENCE SIMILARITIES

Belongs to the enolase family.

TISSUE SPECIFICITY

The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.

DEVELOPMENTAL STAGE

During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells.

SUBCELLULAR LOCATION

Cytoplasm, Cell membrane.

FUNCTION

Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene. Gamma-enolase is a phosphopyruvate hydratase. Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.