FITC Conjugated Human CD58 Recombinant Rabbit Monoclonal Antibody [PSH02-74]
Catalog# HA720198F
FITC Conjugated Human CD58 Recombinant Rabbit Monoclonal Antibody [PSH02-74]
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FC
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Human
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FITC
Overview
Product Name
FITC Conjugated Human CD58 Recombinant Rabbit Monoclonal Antibody [PSH02-74]
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Recombinant protein within human CD58 aa 29-215 (Extracellular).
Species Reactivity
Human
Validated Applications
FC
Target Molecular Weight
Predicted band size: 28 kDa
Positive Control
Human peripheral blood, human monocytes.
Conjugation
FITC
Clone Number
PSH02-74
Product Features
Form
Liquid
Concentration
/(The concentration of this product may be batch-dependent)
Storage Instructions
Store at 2-8℃. Avoid freeze.
Storage Buffer
Supplied in phosphate-buffered solution, pH 7.2, containing 0.2% ProClean 950 and BSA.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
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FC
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5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Target
Function
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
Background References
1. Zhang Y et al. CD58 Immunobiology at a Glance. Front Immunol. 2021 Jun
2. Yan X et al. CD58 loss in tumor cells confers functional impairment of CAR T cells. Blood Adv. 2022 Nov
Subcellular Location
Cell membrane.
UNIPROT
Synonyms
AG3 antibody
CD58 antibody
CD58 antigen (lymphocyte function associated antigen 3)1 antibody
CD58 antigen antibody
CD58 antigen, (lymphocyte function associated antigen 3) antibody
CD58 molecule antibody
FLJ23181 antibody
FLJ43722 antibody
LFA 3 antibody
LFA-3 antibody
ExpandImages
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Flow cytometric analysis of human peripheral blood labelling Human CD58 (HA720198F, FITC).
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Flow cytometric analysis of human monocytes labeling Human CD58.
Cells were washed twice with cold PBS and resuspend. Then incubated for 1 hour at +4℃ with Human CD58 (HA720198F, red, 2μg/mL) and Rabbit IgG Isotype Control (FITC, black, 2μg/mL).
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"