iFluor™ 488 Conjugated CD31 Recombinant Rabbit Monoclonal Antibody [SU03-59]

Function

PECAM-1 is a cell-cell adhesion protein which interacts with other PECAM-1 molecules through homophilic interactions or with non-PECAM-1 molecules through heterophilic interactions. Homophilic interactions between PECAM-1 molecules are mediated by antiparallel interactions between extracellular Ig-like domain 1 and Ig-like domain 2. These interactions are regulated by the level of PECAM-1 expression. Homophilic interactions occur, only when the surface expression of PECAM-1 is high. Otherwise, when expression is low, heterophilic interactions occur.

Background References

1. Doi H et al. Potency of umbilical cord blood- and Wharton\'s jelly-derived mesenchymal stem cells for scarless wound healing. Sci Rep 6:18844 (2016).

2. Yang Y et al. The Increased Expression of Connexin and VEGF in Mouse Ovarian Tissue Vitrification by Follicle Stimulating Hormone. Biomed Res Int 2015:397264 (2015).

Subcellular Location

Cell junction. Cell membrane. Membrane.

UNIPROT

SwissProt: P16284 Human

Synonyms