TCEB2 Recombinant Rabbit Monoclonal Antibody [JE65-72] (HA721002)

UNIPROT #

Q15370

PROTEIN NAME

TCEB2

SYNONYMS

EloB antibody;ELOB_HUMAN antibody;Elongin 18 kDa subunit antibody;Elongin B antibody;Elongin-B antibody;RNA polymerase II transcription factor SIII p18 subunit antibody;RNA polymerase II transcription factor SIII subunit B antibody;SIII antibody;SIII p18 antibody;TCEB 2 antibody;Tceb2 antibody;Transcription elongation factor B (SIII) polypeptide 2 antibody;Transcription elongation factor B polypeptide 2 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Elongin B is a protein that in humans is encoded by the ELOB gene.Elongin B is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.