P2Y12 Recombinant Rabbit Monoclonal Antibody [JE63-23] (HA721011)

UNIPROT #

Q9H244

PROTEIN NAME

P2Y12

SYNONYMS

ADP glucose receptor antibody;ADP-glucose receptor antibody;ADPG R antibody;ADPG-R antibody;ADPGR antibody;BDPLT8 antibody;G protein coupled receptor SP1999 antibody;Gi coupled ADP receptor HORK 3 antibody;Gi coupled ADP receptor HORK3 antibody;HORK 3 antibody;HORK3 antibody;P2RY 12 antibody;P2RY12 antibody;P2T(AC) antibody;P2Y 12 antibody;P2Y purinoceptor 12 antibody;P2Y(12)R antibody;P2Y(AC) antibody;P2Y(ADP) antibody;P2Y(cyc) antibody;P2Y12 antibody;P2Y12 platelet ADP receptor antibody;P2Y12_HUMAN antibody;Platelet ADP receptor antibody;Purinergic receptor P2RY12 antibody;Purinergic receptor P2Y G protein coupled 12 antibody;Purinergic receptor P2Y12 antibody;Putative G protein coupled receptor antibody;SP 1999 antibody;SP1999 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

P2Y12 is a chemoreceptor for adenosine diphosphate (ADP) that belongs to the Gi class of a group of G protein-coupled (GPCR) purinergic receptors. This P2Y receptor family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. The P2Y12 receptor is involved in platelet aggregation and is thus a biological target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene. In the field of purinergic signaling, the P2Y12 protein on the periphery is found mainly but not exclusively on the surface of blood platelets, and is an important regulator in blood clotting. In the central nervous system, this receptor has been found expressed exclusively on microglia, where it is necessary for physiological and pathological microglial actions, such as monitoring neuronal functions and microglial neuroprotection.