BLNK Recombinant Rabbit Monoclonal Antibody [JE63-50]

Function

The B-cell linker protein is encoded by the BLNK gene and is an adaptor protein also known as SLP-65, BASH, and BCA. BLNK is expressed in B cells and macrophages and plays a large role in B cell receptor signalling, in a fashion analogous to the role its paralogue SLP-76 plays in T cell receptor signalling. As it has no known intrinsic enzymatic activity, the function of BLNK is to temporally and spatially coordinate and regulate signalling effectors downstream of the B cell receptor. The function of BLNK was first illustrated in BLNK deficient DT40 cells, a chicken B-cell line, which exhibited an abrogated intracellular calcium mobilisation response and impaired activation of MAP kinases p38, JNK, and to a lesser degree ERK upon B-cell receptor (BCR) activation as compared to wild type DT40 cells. In knockout mice, BLNK deficiency results in a partial block in B-cell development, and in humans BLNK deficiency results in a much more profound block in B-cell development. Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. The B-cell linker protein is essential for normal B-cell development.

Background References

1. Zhang P. et. al. Involvement of Blnk and Foxo1 in tumor suppression in BCR-ABL1-transformed pro-B cells. Oncol Rep. 2021 Feb

2. Han Y. et. al. Lamprey VLRB participates in pathogen detection, VLRB/L-BLNK/L-NF-kappaB (B-like cells) signal transduction, and development. Fish Shellfish Immunol. 2020 Oct

Subcellular Location

Cytoplasm, Cell membrane.

UNIPROT

SwissProt: Q8WV28 Human

SwissProt: Q9QUN3 Mouse

SwissProt: Q4KM52 Rat

Synonyms