TPMT Recombinant Rabbit Monoclonal Antibody [JE64-09]

Function

Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene. A pseudogene for this locus is located on chromosome 18q. Thiopurine methyltransferase methylates thiopurine compounds. The methyl donor is S-adenosyl-L-methionine, which is converted to S-adenosyl-L-homocysteine. This enzyme metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents and immunosuppressive drugs. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. About 1/300 individual is deficient for the enzyme. Genetic variants of TPMT have also been associated with cisplatin-induced ototoxicity in children. TPMT is now listed as a pharmacogenomic biomarker for adverse drug reactions to cisplatin by the FDA.

Background References

1. Mhanna M. et. al. TPMT Genotype and Adverse Effects of Azathioprine among Jordanian Group. Curr Drug Metab. 2019

2. Harmand PO. et. al. Thiopurine Drugs in the Treatment of Ulcerative Colitis: Identification of a Novel Deleterious Mutation in TPMT. Genes (Basel). 2020 Oct

Subcellular Location

Cytoplasm.

UNIPROT

SwissProt: P51580 Human

SwissProt: O55060 Mouse

SwissProt: Q9Z0T0 Rat

Synonyms

HGNC:12014 antibody

S adenosyl L methionine thiopurine S methyltransferase antibody

Thiopurine methyltransferase antibody

Thiopurine S methyltransferase antibody

Thiopurine S-methyltransferase antibody

TPMT antibody

TPMT_HUMAN antibody