CRCP Recombinant Rabbit Monoclonal Antibody [JE65-42] (HA721062)

UNIPROT #

O75575

PROTEIN NAME

CRCP

SYNONYMS

Calcitonin gene related peptide receptor component antibody;Calcitonin gene related peptide receptor component protein antibody;Calcitonin gene-related peptide-receptor component protein antibody;CGRP receptor component protein antibody;CGRP-RCP antibody;CGRP-receptor component protein antibody;CGRPRCP antibody;CRCP antibody;DNA-directed RNA polymerase III subunit RPC9 antibody;HsC17 antibody;RCP antibody;RCP9 antibody;RNA polymerase III subunit C9 antibody;RPC9_HUMAN antibody

SUBCELLULAR LOCATION

Cell membrane, Nucleus.

FUNCTION

This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF-Kappa-B through the RIG-I pathway (By similarity).