EMC4 Recombinant Rabbit Monoclonal Antibody [JE65-17] (HA721082)

UNIPROT #

Q5J8M3

PROTEIN NAME

EMC4

SYNONYMS

Cell proliferation-inducing gene 17 protein antibody;EMC4 antibody;ER membrane protein complex subunit 4 antibody;HSPC184 antibody;PIG17 antibody;tmem85 antibody;TMM85_HUMAN antibody;Transmembrane protein 85 antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane.

FUNCTION

Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).