CD13 Recombinant Rabbit Monoclonal Antibody [PD00-39] (HA721160)

UNIPROT #

P15144

PROTEIN NAME

CD13

SYNONYMS

Alanyl (membrane) aminopeptidase antibody;Alanyl aminopeptidase antibody;Aminopeptidase M antibody;Aminopeptidase N antibody;AMPN_HUMAN antibody;ANPEP antibody;AP M antibody;AP N antibody;AP-M antibody;AP-N antibody;APN antibody;CD 13 antibody;CD13 antibody;CD13 antigen antibody;gp150 antibody;hAPN antibody;LAP 1 antibody;LAP1 antibody;Microsomal aminopeptidase antibody;Myeloid plasma membrane glycoprotein CD13 antibody;p150 antibody;PEPN antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma.