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SQSTM1 / p62 Recombinant Rabbit Monoclonal Antibody [PS00-61] (HA721171)

Price: Regular price $385.00

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Catalog# HA721171

Rabbit Monoclonal to SQSTM1 / p62

Tested for

  • WB

  • IHC-P

  • IF-Cell

  • FC

  • IF-Tissue

  • IHC-Fr

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

SQSTM1 / p62 Recombinant Rabbit Monoclonal Antibody [PS00-61] (HA721171)

Immunogen

Synthetic peptide within human sqstm1/ p62 aa 400 to the c-terminus

Host

Rabbit

Positive Control

HeLa cell lysate, HeLa treated with 50μM Chloroquine for 18 hours cell lysate, NIH/3T3 cell lysate, C2C12 cell lysate, PC-12 cell lysate, SH-SY5Y cell lysate, PANC-1 cell lysate, C2C12, PC-12, A549, human colon carcinoma tissue, human liver tissue, mouse liver tissue, rat liver tissue, mouse brain tissue, rat brain tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

PS00-61

RRID

AB_3072293

APPLICATION DILUTION

  • WB

  • 1:5,000-1:10,000

  • IHC-P

  • 1:1,000-1:2,000

  • IF-Cell

  • 1:100-1:1,000

  • FC

  • 1:1,000

  • IF-Tissue

  • 1:200-1:1,000

  • IHC-Fr

  • 1:500

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 48 kDa

Isotype

IgG

TARGET

UNIPROT #

Q13501

PROTEIN NAME

SQSTM1 / p62

SYNONYMS

A170 antibody;DMRV antibody;EBI 3 associated protein of 60 kDa antibody;EBI 3 associated protein p60 antibody;EBI3 associated protein of 60 kDa antibody;EBI3 associated protein p60 antibody;EBI3-associated protein of 60 kDa antibody;EBIAP antibody;FTDALS3 antibody;MGC127197 antibody;ORCA antibody;OSF-6 antibody;Osi antibody;OSIL antibody;Oxidative stress induced like antibody;p60 antibody;p62 antibody;p62B antibody;Paget disease of bone 3 antibody;PDB 3 antibody;PDB3 antibody;Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa antibody;Phosphotyrosine independent ligand for the Lck SH2 domain p62 antibody;Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa antibody;PKC-zeta-interacting protein antibody;Protein kinase C-zeta-interacting protein antibody;Sequestosome 1 antibody;Sequestosome-1 antibody;SQSTM 1 antibody;SQSTM_HUMAN antibody;Sqstm1 antibody;STAP antibody;STONE14 antibody;Ubiquitin binding protein p62 antibody;Ubiquitin-binding protein p62 antibody;ZIP 3 antibody;ZIP antibody;ZIP3 antibody

SUBCELLULAR LOCATION

Cytoplasm, Endoplasmic reticulum, Endosome, Lysosome, Nucleus.

FUNCTION

Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD. May be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes. Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes.

CITATIONS

  • Cai Y, Yu Z, Yang X, et al

    Integrative transcriptomic and network pharmacology analysis reveals the neuroprotective role of BYHWD through enhancing autophagy by inhibiting Ctsb in intracerebral hemorrhage mice

  • Chunxue Zhang,et al

    Developing patient-derived organoids to identify JX24120 inhibit SAMe synthesis in endometrial cancer by targeting MAT2B

  • Discovery of Novel 1,2,3,4-Tetrahydrobenzofuro[2,3-c]pyridine Histone Deacetylase Inhibitors for Efficient Treatment of Hepatocellular Carcinoma

  • STAT3 phosphorylation mediates high glucose-impaired cell autophagy in an HDAC1-dependent and -independent manner in Schwann cells of diabetic peripheral neuropathy.

  • The novel LSD1 inhibitor ZY0511 suppresses diffuse large B-cell lymphoma proliferation by inducing apoptosis and autophagy

  • Zhang, T., Rao, Q., Dai, M., Wu, Z. E., Zhao, Q., & Li, F.

    Tripterygium wilfordii protects against an animal model of autoimmune hepatitis

  • Aixin Hu , Wenxia Huang , Xin Shu , Shiyue Ma , Caimei Yang , Ruiqiang Zhang , Xiao Xiao , Yanping Wu

    Lactiplantibacillus plantarum Postbiotics Suppress Salmonella Infection via Modulating Bacterial Pathogenicity, Autophagy and Inflammasome in Mice

  • Li Jiaxin,et al

    Genipin Activates Autophagy and Promotes Myoblast Differentiation by Activating AMPK Pathway

  • Crizotinib induces pulmonary toxicity by blocking autophagy flux in alveolar epithelial cells

  • Zhu Chengke,et al

    Pathogenicity characterization, immune response mechanisms, and antiviral strategies analysis underlying a LMBV strain in largemouth bass (Micropterus salmoides)

  • Zhang Ting,et al

    PDCD4 Inhibition Alleviates Neuropathic Pain by regulating Spinal Autophagy and neuroinflammation

  • Zhao Yuan,et al

    FGL2 Improves Experimental Colitis Related to Gut Microbiota Structure and Bile Acid Metabolism by Regulating Macrophage Autophagy and Apoptosis

  • Han Zheng,et al

    Acteoside alleviates lipid peroxidation by enhancing Nrf2-mediated mitophagy to inhibit ferroptosis for neuroprotection in Parkinson's disease

  • Yu H, Xie L, Chen Z, et al

    miR-22a targets p62/SQSTM1 to negatively affect autophagy and disease resistance of grass carp (Ctenopharyngodon idella)

  • Gao Shuai,et al

    Gonococcal OMV-delivered PorB induces epithelial cell mitophagy

  • Autophagy participates in germline cyst breakdown and follicular formation by modulating glycolysis switch via Akt signaling in newly-hatched chicken ovaries

  • Inhibition of STX17–SNAP29–VAMP8 complex formation by costunolide sensitizes ovarian cancer cells to cisplatin via the AMPK/mTOR signaling pathway

  • Hu Qidi,et al

    Adenosine A2A receptor antagonist KW6002 protects against A53T mutant alpha-synuclein-induced brain damage and neuronal apoptosis in Parkinson's disease mice by restoring autophagic flux

  • Liu Xinying,et al

    Genipin promotes the apoptosis and autophagy of neuroblastoma cells by suppressing the PI3K/AKT/mTOR pathway

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