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PSME2 Recombinant Rabbit Monoclonal Antibody [PSH0-10] (HA721263)

Price: Regular price $385.00

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Catalog# HA721263

Rabbit Monoclonal to PSME2

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

PSME2 Recombinant Rabbit Monoclonal Antibody [PSH0-10] (HA721263)

Immunogen

Recombinant protein within human aa 2-239.

Host

Rabbit

Positive Control

PC-12 cell lysate, 293T cell lysate, mouse liver tissue lysate, rat thymus tissue lysate, MCF-7 cell lysate, PC-3 cell lysate, Hela, rat stomach tissue, human rectal carcinoma tissue, HepG2.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

PSH0-10

RRID

AB_3072380

APPLICATION DILUTION

  • WB

  • 1:1,000-1:5,000

  • IF-Cell

  • 1:100

  • IHC-P

  • 1:4,000

  • FC

  • 1:500-1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 27 kDa

Isotype

IgG

TARGET

UNIPROT #

Q9UL46

PROTEIN NAME

PSME2

SYNONYMS

11S regulator complex beta subunit antibody;11S regulator complex subunit beta antibody;Activator of multicatalytic protease subunit 2 antibody;Cell migration inducing protein 22 antibody;MCP activator 31 kD subunit antibody;PA28 beta antibody;PA28b antibody;PA28beta antibody;Proteasome (prosome macropain) activator subunit 2 (PA28 beta) antibody;Proteasome (prosome macropain) activator subunit 2 antibody;Proteasome activator 28 beta antibody;Proteasome activator 28 subunit beta antibody;Proteasome activator complex subunit 2 antibody;Proteasome activator hPA28 subunit beta antibody;Proteasome activator subunit 2 antibody;PSME 2 antibody;PSME2 antibody;PSME2_HUMAN antibody;REG beta antibody;REG-beta antibody;REGbeta antibody

SUBCELLULAR LOCATION

Cytosol, Extracellular region or secreted, Nucleus.

FUNCTION

Proteasome activator complex subunit 2 is a protein that in humans is encoded by the PSME2 gene. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.

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