Pyruvate Dehydrogenase E2 Recombinant Rabbit Monoclonal Antibody [JE34-38] (HA721267)

UNIPROT #

P10515

PROTEIN NAME

Pyruvate Dehydrogenase E2

SYNONYMS

70 kDa mitochondrial autoantigen of primary biliary cirrhosis antibody;Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex antibody;Dihydrolipoamide S Acetyltransferase antibody;Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex antibody;dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial antibody;DLAT antibody;DLTA antibody;E2 antibody;E2 component of pyruvate dehydrogenase complex antibody;M2 antigen complex 70 kDa subunit antibody;mitochondrial antibody;ODP2_HUMAN antibody;PBC antibody;PDC E2 antibody;PDC-E2 antibody;PDCE2 antibody;Pyruvate dehydrogenase complex component E2 antibody;Pyruvate dehydrogenase complex E2 subunit antibody

SUBCELLULAR LOCATION

Mitochondrion matrix.

FUNCTION

Dihydrolipoyl transacetylase (or dihydrolipoamide acetyltransferase) is an enzyme component of the multienzyme pyruvate dehydrogenase complex. The pyruvate dehydrogenase complex is responsible for the pyruvate decarboxylation step that links glycolysis to the citric acid cycle. This involves the transformation of pyruvate from glycolysis into acetyl-CoA which is then used in the citric acid cycle to carry out cellular respiration. There are three different enzyme components in the pyruvate dehydrogenase complex. Pyruvate dehydrogenase (EC 1.2.4.1) is responsible for the oxidation of pyruvate, dihydrolipoyl transacetylase (this enzyme; EC 2.3.1.12) transfers the acetyl group to coenzyme A (CoA), and dihydrolipoyl dehydrogenase (EC 1.8.1.4) regenerates the lipoamide. Because dihydrolipoyl transacetylase is the second of the three enzyme components participating in the reaction mechanism for conversion of pyruvate into acetyl CoA, it is sometimes referred to as E2. In humans, dihydrolipoyl transacetylase enzymatic activity resides in the pyruvate dehydrogenase complex component E2 (PDCE2) that is encoded by the DLAT (dihydrolipoamide S-acetyltransferase) gene.