RAP1A + RAP1B Recombinant Rabbit Monoclonal Antibody [JE35-61] (HA721335)

UNIPROT #

P62834

PROTEIN NAME

RAP1A + RAP1B

SYNONYMS

C21KG antibody;G 22K antibody;G-22K antibody;GTP binding protein smg p21A antibody;GTP-binding protein smg p21A antibody;KREV 1 antibody;KREV1 antibody;OTTHUMP00000013741 antibody;RAP 1A antibody;RAP1 antibody;RAP1A antibody;RAP1A member of RAS oncogene family antibody;RAP1A_HUMAN antibody;Ras related protein Krev 1 antibody;Ras related protein Rap 1A antibody;RAS related protein RAP1A antibody;Ras-related protein Krev-1 antibody;Ras-related protein Rap-1A antibody;SMGP21 antibody;GTP-binding protein smg p21B antibody;K-REV antibody;OK/SW-cl.11 antibody;RAL1B antibody;rap1b antibody;RAP1B member of RAS oncogene family antibody;RAP1B_HUMAN antibody;Ras family small GTP binding protein RAP1B antibody;RAS related protein RAP1B antibody;Ras-related protein Rap-1b antibody;Small GTP binding protein antibody

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, Cytoplasm, perinuclear region, Cell junction, Early endosome; Cell membrane, Cytoplasm, cytosol, Cell junction.

FUNCTION

RAP1A: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. RAP1B: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.