FADD Recombinant Rabbit Monoclonal Antibody [JE45-25] (HA721353)

UNIPROT #

Q13158

PROTEIN NAME

FADD

SYNONYMS

FADD antibody;FADD protein antibody;FADD_HUMAN antibody;Fas (TNFRSF6) associated via death domain antibody;Fas associated via death domain antibody;Fas associating death domain containing protein antibody;Fas associating protein antibody;Fas associating protein with death domain antibody;Fas TNFRSF6 associated via death domain antibody;FAS-associated death domain protein antibody;FAS-associating death domain-containing protein antibody;GIG 3 antibody;GIG3 antibody;Growth inhibiting gene 3 protein antibody;Growth-inhibiting gene 3 protein antibody;H sapiens mRNA for mediator of receptor induced toxicity antibody;Mediator of receptor induced toxicity antibody;MGC8528 antibody;MORT 1 antibody;MORT1 antibody;Protein FADD antibody

SUBCELLULAR LOCATION

Cytoplasm, cytosol, neuron projection, nucleus, plasma membrane, ripoptosome.

FUNCTION

FAS-associated death domain protein, also called MORT1, is encoded by the FADD gene on the 11q13.3 region of chromosome 11 in humans. FADD is an adaptor protein that bridges members of the tumor necrosis factor receptor superfamily, such as the Fas-receptor, to procaspases 8 and 10 to form the death-inducing signaling complex (DISC) during apoptosis. As well as its most well known role in apoptosis, FADD has also been seen to play a role in other processes including proliferation, cell cycle regulation and development.