NDP52 Recombinant Rabbit Monoclonal Antibody [PSH02-33]

Function

NDP52 is a xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. It acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation. Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C. May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion.

Background References

1. Fili N, et al. NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription. Nat Commun 8:1871 (2017).

2. Li W, et al. Fasudil prevents neomycin-induced hair cell damage by inhibiting autophagy through the miR-489/NDP52 signaling pathway in HEI-OC1 cells. Exp Ther Med 23:43 (2022).

Subcellular Location

Cytoplasm, perinuclear region, cytoskeleton, cytoplasmic vesicle, autophagosome membrane

UNIPROT

SwissProt: Q13137 Human

Synonyms