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ROS1 Recombinant Rabbit Monoclonal Antibody [PD01-27]

Usd: 385

Specification

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Catalog# HA721420

ROS1 Recombinant Rabbit Monoclonal Antibody [PD01-27]

Application

  • IHC-P

Reactivity

  • Human

BSA and Azide free
Conjugation

  • unconjugated

Overview

Product Name

ROS1 Recombinant Rabbit Monoclonal Antibody [PD01-27]

Antibody Type

Recombinant Rabbit monoclonal Antibody

Immunogen

Synthetic peptide within Human ROS1 aa 2050-2150.

Species Reactivity

Human

Validated Applications

IHC-P

Molecular Weight

Predicted band size: 264 kDa

Positive Control

Human lung carcinoma tissue.

Conjugation

unconjugated

Clone Number

PD01-27

RRID

AB_3072537

Product Features

Form

Liquid

Concentration

Storage Instructions

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.

Storage Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Isotype

IgG

Purification Method

Protein A affinity purified.

Application Dilution

  • IHC-P

  • 1:200

Target

Function

Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene. This proto-oncogene, highly expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.

Background References

1. Drilon A et al. ROS1-dependent cancers - biology, diagnostics and therapeutics. Nat Rev Clin Oncol. 2021 Jan

2. Drilon A et al. Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1-2 trials. Lancet Oncol. 2020 Feb

Subcellular Location

Cell membrane.

UNIPROT

SwissProt: P08922 Human

Synonyms

c ros 1 antibody

c ros antibody

c ros oncogene 1 receptor tyrosine kinase antibody

c Ros receptor tyrosine kinase antibody

c ros1 antibody

MCF 3 antibody

MCF3 antibody

Oncogene ROS antibody

OTTHUMP00000017814 antibody

OTTHUMP00000017815 antibody

Expand

Images

  • Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue with Rabbit anti-ROS1 antibody (<a href="/products/HA721420" style="font-weight: bold;text-decoration: underline;">HA721420</a>) at 1/200 dilution.<br /><br />The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH<sub>2</sub>O and PBS, and then probed with the primary antibody (<a href="/products/HA721420" style="font-weight: bold;text-decoration: underline;">HA721420</a>) at 1/200 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

    Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue with Rabbit anti-ROS1 antibody (HA721420) at 1/200 dilution.

    The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (HA721420) at 1/200 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"