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hCG beta Recombinant Rabbit Monoclonal Antibody [JE45-04]

Usd: 385

Specification

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Catalog# HA721437

hCG beta Recombinant Rabbit Monoclonal Antibody [JE45-04]

Application

  • IHC-P

Reactivity

  • Human

Conjugation

  • unconjugated

Overview

Product Name

hCG beta Recombinant Rabbit Monoclonal Antibody [JE45-04]

Antibody Type

Recombinant Rabbit monoclonal Antibody

Immunogen

Full length protein corresponding to Human hCG beta.

Species Reactivity

Human

Validated Applications

IHC-P

Molecular Weight

Predicted band size: 17 kDa

Positive Control

Human placenta tissue.

Conjugation

unconjugated

Clone Number

JE45-04

RRID

AB_3072553

Product Features

Form

Liquid

Concentration

Storage Instructions

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Isotype

IgG

Purification Method

Protein A affinity purified.

Application Dilution

  • IHC-P

  • 1:1,000

Target

Function

Choriogonadotropin subunit beta (CG-beta) also known as chorionic gonadotrophin chain beta is a protein that in humans is encoded by the CGB gene. This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.

Background References

1. Fisher K et al. Beta-HCG-producing phyllodes tumor. Breast J. 2020 Mar

2. Hughes LM et al. Early β-hCG levels predict live birth after single embryo transfer. J Assist Reprod Genet. 2022 Oct

Subcellular Location

Secreted.

UNIPROT

SwissProt: P0DN86 Human

SwissProt: P0DN87 Human

SwissProt: Q6NT52 Human

Synonyms

CG beta antibody

CG-beta antibody

CgB antibody

CGB3 antibody

CGB3_HUMAN antibody

CGB5 antibody

CGB7 antibody

CGB7_HUMAN antibody

CGB8 antibody

CGHB_HUMAN antibody

Expand

Images

  • Immunohistochemical analysis of paraffin-embedded human placenta tissue with Rabbit anti-hCG beta antibody (<a href="/products/HA721437" style="font-weight: bold;text-decoration: underline;">HA721437</a>) at 1/1,000 dilution.<br /><br />The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH<sub>2</sub>O and PBS, and then probed with the primary antibody (<a href="/products/HA721437" style="font-weight: bold;text-decoration: underline;">HA721437</a>) at 1/1,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

    Immunohistochemical analysis of paraffin-embedded human placenta tissue with Rabbit anti-hCG beta antibody (HA721437) at 1/1,000 dilution.

    The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (HA721437) at 1/1,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"