hCG beta Recombinant Rabbit Monoclonal Antibody [JE45-04]
Catalog# HA721437
hCG beta Recombinant Rabbit Monoclonal Antibody [JE45-04]
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IHC-P
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Human
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unconjugated
Overview
Product Name
hCG beta Recombinant Rabbit Monoclonal Antibody [JE45-04]
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Full length protein corresponding to Human hCG beta.
Species Reactivity
Human
Validated Applications
IHC-P
Target Molecular Weight
Predicted band size: 17 kDa
Positive Control
Human placenta tissue.
Conjugation
unconjugated
Clone Number
JE45-04
RRID
Product Features
Form
Liquid
Concentration
1 mg/mL.(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
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IHC-P
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1:1,000
Target
Function
Choriogonadotropin subunit beta (CG-beta) also known as chorionic gonadotrophin chain beta is a protein that in humans is encoded by the CGB gene. This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.
Background References
1. Fisher K et al. Beta-HCG-producing phyllodes tumor. Breast J. 2020 Mar
2. Hughes LM et al. Early β-hCG levels predict live birth after single embryo transfer. J Assist Reprod Genet. 2022 Oct
Subcellular Location
Secreted.
Synonyms
CG beta antibody
CG-beta antibody
CgB antibody
CGB3 antibody
CGB3_HUMAN antibody
CGB5 antibody
CGB7 antibody
CGB7_HUMAN antibody
CGB8 antibody
CGHB_HUMAN antibody
ExpandImages
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Immunohistochemical analysis of paraffin-embedded human placenta tissue with Rabbit anti-hCG beta antibody (HA721437) at 1/1,000 dilution.
The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (HA721437) at 1/1,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"