CRBN Recombinant Rabbit Monoclonal Antibody [PSH0-69] (HA721457)

UNIPROT #

Q96SW2

PROTEIN NAME

CRBN

SYNONYMS

2610203G15Rik antibody;2900045O07Rik antibody;AF229032 antibody;AW108261 antibody;Cereblon antibody;Crbn antibody;CRBN_HUMAN antibody;DKFZp781K0715 antibody;MGC27358 antibody;MRT2A antibody;OTTHUMP00000209555 antibody;piL antibody;Protein cereblon antibody;Protein x 0001 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Membrane.

FUNCTION

Cereblon is a protein that in humans is encoded by the CRBN gene. The gene that encodes the cereblon protein is found on the human chromosome 3, on the short arm at position p26.3 from base pair 3,190,676 to base pair 3,221,394. CRBN orthologs are highly conserved from plants to humans. Cereblon forms an E3 ubiquitin ligase complex with damaged DNA binding protein 1 (DDB1), Cullin-4A (CUL4A), and regulator of cullins 1 (ROC1). This complex ubiquitinates a number of other proteins. Through a mechanism which has not been completely elucidated, this ubiquitination results in reduced levels of fibroblast growth factor 8 (FGF8) and fibroblast growth factor 10 (FGF10). FGF8 in turn regulates a number of developmental processes, such as limb and auditory vesicle formation. The net result is that this ubiquitin ligase complex is important for limb outgrowth in embryos. In the absence of cereblon, DDB1 forms a complex with DDB2 that functions as a DNA damage-binding protein. Furthermore, cereblon and DDB2 bind to DDB1 in a competitive manner.