TRF1 Recombinant Rabbit Monoclonal Antibody [JE59-70]

Function

The human TERF1 gene is located in the chromosome 8 at 73,921,097-73,960,357 bp. Two transcripts of this gene are alternatively spliced products.[6] The TERF1 gene is also known as TRF, PIN2 (Proteinase Inhibitor 2), TRF1, t-TRF1 and h-TRF1-AS. TERF 1 gene encodes a telomere specific protein which is a component of the telomere's shelterin nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. It is known to protect telomeres in mammals from DNA mechanisms that are used for repair purposes and at the same time regulate the activity carried out by telomerase. The telomeric repeat binding factor 1 protein is present at telomeres, where the cells aging aspect is monitored, throughout the typical cell cycle process. The progressive loss of the telomeric ends of chromosomes is an important mechanism in the timing of human cellular aging. Telomeric Repeat Factor 1 (TRF1) is a protein that binds at telomere ends. The protein has the ultimate use of functioning as an inhibitor of telomerase, a protein enzyme that assists in the elongation of chromosomes by the addition of sequences of TTAGGG to the end of the chromosomes. The protein acts as cis-regulatory elements in the process of limiting the ends of individual chromosomes from elongating as facilitated by telomerase and the TTAGGG sequences. The structure of the protein consists of a dimerization domain close to its amino terminus, a carboxyl terminal tail, which is the free carboxyl group that terminates the end of a protein chain and an acidic amino terminus, which is the free amine group that terminates the start of a protein.

Background References

1. Yang Z et al. TRF1 uses a noncanonical function of TFIIH to promote telomere replication. Genes Dev. 2022 Sep

2. Li X et al. Dynamics of TRF1 organizing a single human telomere. Nucleic Acids Res. 2021 Jan

Subcellular Location

Nucleus, Cytoplasm, cytoskeleton, spindle, Chromosome, telomere.

UNIPROT

SwissProt: P54274 Human

SwissProt: P70371 Mouse

Synonyms