KIM-1/HAVCR1 Recombinant Rabbit Monoclonal Antibody [JE39-41]

Function

Hepatitis A virus cellular receptor 1 (HAVcr-1) also known as T-cell immunoglobulin and mucin domain 1 (TIM-1) is a protein that in humans is encoded by the HAVCR1 gene. It is also known as KIM-1 Kidney Injury Molecule -1, which is a type 1 transmembrane protein the most highly upregulated in injured kidneys by various types of insults. Its upregulation during renal injury has been found in the kidneys of the vertebrates such as Zebrafish and humans. The hepatitis A virus cellular receptor 1 (HAVCR1/TIM-1), is a member of the TIM (T cell transmembrane, immunoglobulin, and mucin) gene family, which plays critical roles in regulating immune cell activity especially regarding the host response to viral infection. TIM-1 is also involved in allergic response, asthma, and transplant tolerance. The TIM gene family was first cloned from the mouse model of asthma in 2001. Subsequently, it was demonstrated that members of the TIM gene family including TIM-1 participate in host immune response. The mouse TIM gene family contains eight members (TIM-1-8) while only three TIM genes (TIM-1, TIM-3, and TIM-4) have been identified in humans.

Background References

1. Angiari S., Donnarumma T., Rossi B., Dusi S., Pietronigro E., Zenaro E., Della Bianca V., Toffali L., Piacentino G., Budui S., Rennert P., Xiao S., Laudanna C., Casasnovas J.M., Kuchroo V.K., Constantin G. TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. Immunity 40:542-553 (2014)

2. van Timmeren M.M., van den Heuvel M.C., Bailly V., Bakker S.J., van Goor H., Stegeman C.A. Tubular kidney injury molecule-1 (KIM-1) in human renal disease. J. Pathol. 212:209-217 (2007)

Subcellular Location

Cell membrane.

UNIPROT

SwissProt: Q96D42 Human

SwissProt: Q5QNS5 Mouse

SwissProt: O54947 Rat

Synonyms