Rab3A Recombinant Rabbit Monoclonal Antibody [PSH01-08] (HA721573)

UNIPROT #

P20336

PROTEIN NAME

Rab3A

SYNONYMS

Rab 3A antibody;RAB 3A member RAS oncogene family antibody;Rab3a antibody;RAB3A member RAS oncogene family antibody;RAB3A_HUMAN antibody;RAS associated protein RAB 3A antibody;RAS associated protein RAB3A antibody;Ras related protein Rab 3A antibody;Ras related protein Rab3A antibody;Ras-related protein Rab-3A antibody

SUBCELLULAR LOCATION

Cytoplasm, cytosol, Lysosome, Cytoplasmic vesicle, secretory vesicle, Cell projection, axon, Cell membrane, Presynapse, Postsynapse.

FUNCTION

Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9. Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1. Also plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity). Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity).