IFT88 Recombinant Rabbit Monoclonal Antibody [JE64-77] (HA721590)

UNIPROT #

Q13099

PROTEIN NAME

IFT88

SYNONYMS

D13S1056E antibody;DAF19 antibody;hTg737 antibody;Ift88 antibody;IFT88_HUMAN antibody;Intraflagellar transport 88 homolog antibody;Intraflagellar transport protein 88 homolog antibody;MGC26259 antibody;Polaris homolog antibody;Probe hTg737 (polycystic kidney disease, autosomal recessive) antibody;Recessive polycystic kidney disease protein Tg737 homolog antibody;RP11-172H24.2 antibody;Tetratricopeptide repeat domain 10 antibody;Tetratricopeptide repeat protein 10 antibody;TG737 antibody;TPR repeat protein 10 antibody;TTC10 antibody

SUBCELLULAR LOCATION

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole, Cell projection, cilium, cilium basal body, flagellum.

FUNCTION

Intraflagellar transport protein 88 homolog is a protein that is encoded by the IFT88 gene. This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. In 2012 a mutation was found to be responsible for a novel form of ciliopathy and anosmia in humans capable of remedy in mice by adenoviral mediated gene therapy. IFT88 has been shown to interact with BAT2 and WDR62.[8][9] WDR62 is required for IFT88 localization to the cilia basal body and the cilia axoneme.