Nucleoporin p62 Recombinant Rabbit Monoclonal Antibody [JE55-09] (HA721594)

UNIPROT #

P37198

PROTEIN NAME

Nucleoporin p62

SYNONYMS

62 kDa nucleoporin antibody;DKFZp547L134 antibody;FLJ20822 antibody;FLJ43869 antibody;IBSN antibody;MGC841 antibody;Nuclear pore glycoprotein p62 antibody;nucleoporin 62kDa antibody;Nucleoporin Nup62 antibody;nucleoporin p62 antibody;nucleoporin p62KD antibody;NUP62 antibody;NUP62 protein antibody;p62 antibody;SNDI antibody

SUBCELLULAR LOCATION

Nucleus, nuclear pore complex, Cytoplasm, cytoskeleton, spindle pole, Nucleus envelope, microtubule organizing center, centrosome.

FUNCTION

Nuclear pore glycoprotein p62 is a protein complex associated with the nuclear envelope. The p62 protein remains associated with the nuclear pore complex-lamina fraction. p62 is synthesized as a soluble cytoplasmic precursor of 61 kDa followed by modification that involve addition of N-acetylglucosamine residues, followed by association with other complex proteins. In humans it is encoded by the NUP62 gene. The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform.