Mitofilin Recombinant Rabbit Monoclonal Antibody [PSH01-18] (HA721635)

UNIPROT #

Q16891

PROTEIN NAME

Mitofilin

SYNONYMS

Cell proliferation inducing protein 52 antibody;Cell proliferation-inducing gene 4/52 protein antibody;Heart muscle protein antibody;HMP antibody;IMMT antibody;IMMT_HUMAN antibody;Inner membrane protein mitochondrial antibody;Inner mitochrondial membrane antibody;MICOS complex subunit MIC60 antibody;MINOS2 antibody;Mitochondrial inner membrane organizing system 2 antibody;Mitochondrial inner membrane protein antibody;Mitofilin antibody;Motor protein antibody;p87 antibody;p87/89 antibody;p89 antibody;pig4 antibody;PIG52 antibody;Proliferation-inducing gene 4 antibody

SUBCELLULAR LOCATION

Mitochondrion inner membrane, Mitochondrion.

FUNCTION

Mitochondrial inner membrane protein is a protein that in humans is encoded by the IMMT gene. IMMT encodes an inner mitochondrial membrane (IMM) protein in the nucleus. It is posttranslational transported to the IMM. Mic60/Mitofilin (encoded by the IMMT gene) is a core subunit of the MICOS-complex, directly located next to cristae junctions (CJ). Human Mic60 exists in two isoforms of different size, anchored to the IMM via its N-terminus, while most of the protein is located to the inner mitochondrial space (IMS). Mic60 is evolutionary one of the oldest MICOS subunits as homologous were found in anaerobic prokaryotes. It is mainly present in two isoforms (ca. 88 and 90 kDa). In the brain, four isoforms are known, which differ in their isoelectric point due to different post-translational modifications. The amino terminus of Mic60 is anchored in the IM, while most of the protein is extended to the IMS. C-terminal Mic60 has a conserved mitofilin domain which is crucial for building the MICOS-complex. A central coiled-coil domain is required to enable protein-protein interactions.