FGF18 Recombinant Rabbit Monoclonal Antibody [PSH01-25]

Function

Fibroblast growth factor 18 is a protein that in humans is encoded by the FGF18 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. FGF18 signals through fibroblast growth factor receptor FGFR3 to promote chondrogenesis and has been shown to cause thickening of cartilage in a murine model of osteoarthritis, and the recombinant version of it (sprifermin) is in clinical trial as a potential treatment for osteoarthritis. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.

Background References

1. Guo K et al. HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway. J Exp Clin Cancer Res. 2022 Mar

2. Yue M et al. Tissue-specific analysis of Fgf18 gene function in palate development. Dev Dyn. 2021 Apr

Subcellular Location

Secreted.

UNIPROT

SwissProt: O89101 Mouse

Synonyms

FGF 18 antibody

FGF-18 antibody

Fgf18 antibody

FGF18_HUMAN antibody

FGFI antibody

Fibroblast growth factor 18 antibody

zFGF5 antibody