Phospho-CRMP2 (T514) Recombinant Rabbit Monoclonal Antibody [JE57-25]

Function

Members of the CRMP family were discovered independently in different species by several groups working in parallel. Among the five members of the family, CRMP-2 was first identified in 1995. Group of researchers led by Goshima found out that CRMP-2 played a role in the transduction of the extracellular Semaphorin 3A (Sema3A), an inhibitory protein for axonal guidance in chick dorsal root ganglion (DRG). The protein was first named as CRMP-62 having a relative molecular mass of 62 kDa and later referred as CRMP-2. Concurrently, a 64 kDa protein named as TOAD-64 for Turned On After Division, was shown to increase significantly during the development of the cortex of the brain. The cDNA sequence of TOAD-64 corresponded to that of rat CRMP-2. In 1996, mouse CRMP-4, often referred to as Ulip for Unc-33 like phosphoprotein, was discovered by Byk and colleagues, using a rabbit polyclonal antiserum which recognized a 64 kDa mouse brain specific phosphoprotein. In the same year, several other studies cloned CRMPs-1-4 in rat and dihydropyrimidinase (DHPase) homologous sequence of CRMPs-1, -2, and -4 in human fetal brain. Finally, in 2000, CRMP-5 was discovered using two-hybrid screenings of brain libraries or purification from a proteic complex. In following researches, CRMPs were studied as target antigens for autoantibodies in various autoimmune neurodegenerative disorders.

Background References

1. Charrier E.; Reibel S.; Rogemond V.; Aguera M.; Thomasset N.; Honnorat J. (August 2003). "Collapsin response mediator proteins (CRMPs) - Involvement in nervous system development and adult neurodegenerative disorders". Molecular Neurobiology. 28 (1): 51–63.

2. Hou ST, Jiang SX, Smith RA (2008). Permissive and repulsive cues and signaling pathways of axonal outgrowth and regeneration. International Review of Cell and Molecular Biology. Vol. 267. pp. 125–181.

Subcellular Location

Cytoplasm. Cytoskeleton.

UNIPROT

SwissProt: Q16555 Human

SwissProt: O08553 Mouse

SwissProt: P47942 Rat

Synonyms