PACT (PKR activating protein) / PRKRA Recombinant Rabbit Monoclonal Antibody [PSH02-15] (HA721774)

UNIPROT #

O75569

PROTEIN NAME

PACT (PKR activating protein) / PRKRA

SYNONYMS

DYT16 antibody;HSD14 antibody;Interferon inducible double stranded RNA dependent protein kinase activator A antibody;interferon-inducible double stranded RNA-dependent activator antibody;Interferon-inducible double stranded RNA-dependent protein kinase activator A antibody;PACT antibody;PKR associated protein X antibody;PKR associating protein X antibody;PKR-associated protein X antibody;PKR-associating protein X antibody;PRKRA antibody;PRKRA_HUMAN antibody;Protein activator of the interferon induced protein kinase antibody;Protein activator of the interferon-induced protein kinase antibody;Protein kinase antibody;Protein kinase interferon inducible double stranded RNA dependent activator antibody;RAX antibody

SUBCELLULAR LOCATION

Cytoplasm, perinuclear region

FUNCTION

PRKRA can activate EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner.