TXNRD2 Recombinant Rabbit Monoclonal Antibody [PSH02-26] (HA721806)

UNIPROT #

Q9NNW7

PROTEIN NAME

TXNRD2

SYNONYMS

mitochondrial antibody;Selenoprotein Z antibody;SelZ antibody;Thioredoxin reductase 2 antibody;Thioredoxin reductase 2 mitochondrial antibody;Thioredoxin reductase 3 antibody;Thioredoxin reductase beta antibody;Thioredoxin reductase TR3 antibody;TR 3 antibody;TR antibody;TR beta antibody;TR-beta antibody;TR3 antibody;TRXR 2 antibody;TRXR2 antibody;TRXR2_HUMAN antibody;TXNRD 2 antibody;Txnrd2 antibody

SUBCELLULAR LOCATION

Mitochondrion.

FUNCTION

The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene.