RNA polymerase beta Recombinant Rabbit Monoclonal Antibody [JE32-42]

Function

DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Resistance to the antibiotics salinamide A, salinamide B, rifampicin, streptolydigin, CBR703, myxopyronin, and lipiarmycin can result from mutations in this protein. Part of the processive rRNA transcription and antitermination complex (rrnTAC). The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNAP. It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis.

Background References

1. Degen D., Feng Y., Zhang Y., Ebright K.Y., Ebright Y.W., Gigliotti M., Vahedian-Movahed H., Mandal S., Talaue M. Transcription inhibition by the depsipeptide antibiotic salinamide A. Elife 3:e02451-e02451 (2014)

2. Huang Y.H., Hilal T., Loll B., Buerger J., Mielke T., Boettcher C., Said N., Wahl M.C. Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis. Mol. Cell 0:0-0 (2020)

Subcellular Location

Cytoplasm

UNIPROT

SwissProt: P0A8V2 Escherichia coli

Entrez Gene: 948488 Escherichia coli

Synonyms